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Outcomes of Other Drugs on VIAGRA Sildenafil metabolism is principally mediated by CYP3A4 (key route) and CYP2C9 (slight route). Therefore, inhibitors of these isoenzymes may possibly reduce sildenafil clearance and inducers of these isoenzymes may well increase sildenafil clearance.It’s imperative that you realize that in contrast to Viagra, the